Blood Pressure Control by Angiotensin in the Brain.

Grant number: 566563 | Funding period: 2009 - 2011

Completed

Abstract

Adequate blood pressure is necessary for normal function. High blood pressure occurs in a proportion of the human population and causes many diseases such as stroke and heart failure. The factors producing high blood pressure are not known for most people who have this condition. We are investigating the role of the brain in the regulation of blood pressure and in this application we are testing whether increased activity in certain brain regions can cause high blood pressure.

Related publications (4)

Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress

D Chen, N Jancovski, JK Bassi, TP Nguyen-Huu, YT Choong, K Palma-Rigo, PJ Davern, SB Gurley, WG Thomas, GA Head, AM Allen

2012-02-08

The rise in blood pressure during an acute aversive stress has been suggested to involve activation of angiotensin type 1A recepto..

Regulation of angiotensinogen by angiotensin II in mouse primary astrocyte cultures

EL O'Callaghan, JK Bassi, ER Porrello, LMD Delbridge, WG Thomas, AM Allen

2011-10-01

Astrocytes are the major source of angiotensinogen in the brain and play an important role in the brain renin-angiotensin system. ..

Renal proximal tubule angiotensin AT1A receptors regulate blood pressure

H Li, ET Weatherford, DR Davis, HL Keen, JL Grobe, A Daugherty, LA Cassis, AM Allen, CD Sigmund

2011-10-01

All components of the renin angiotensin system necessary for ANG II generation and action have been reported to be present in rena..

Expression of angiotensin type 1A receptors in C1 neurons restores the sympathoexcitation to angiotensin in the rostral ventrolateral medulla of angiotensin type 1A knockout mice

D Chen, JK Bassi, T Walther, WG Thomas, AM Allen

2010-07-01

In adult mice we determined whether expression of angiotensin II (Ang II) type 1A receptors (AT1ARs) in C1 neurons mediates the ex..

University of Melbourne Researchers

Andrew Allen